There is a lot of research and information on the web concerning L-Serine. We do not make any claims nor representations about the uses of L-Serine.

We are offering links here (divided by general topic / disorders / conditions) to other web sites and directly to publications that can give you further information. We have no responsibility for any information offered at other sites, nor do we necessarily endorse their information or views.

That said, we have attempted to link with medically reputable sites, standard medical associations or journals and not to advertising nor marketing sites. Please contact us with any concerns or suggestions.

Amyotrophic lateral sclerosis (ALS), aka Lou Gehrig’s Disease

Imposter Amino Acid Mimics Serine, Kinks Neuroproteins, Prompts Tangling

One of Time Magazines 11 “Heroes of Medicine,” Dr. Paul Alan Cox discusses the latest findings concerning ALS and L-Serine in simple language in this TEDx talk:

U.S. National Institutes of Health (NIH) Clinical Trial, “… These findings have led us to believe that high doses of L-serine could possibly stop the mis-incorporation of BMAA into brain proteins which in turn would slow or even abate the progression of ALS.” (From “detailed description”)

The Non-Protein Amino Acid BMAA Is Misincorporated into Human Proteins in Place of l-Serine Causing Protein Misfolding and Aggregation

ALS News Today – Environmental Toxin a Possible Cause of Symptoms of ALS, Alzheimer’s Disease with a link to the clinical paper.

Alzheimer’s Disease and Dementia

There are new studies and information about L-Serine and Alzheimer’s disease. Here is an article in the Washington Post as well as an article in the LA Times science section with good links to the science.

There is further information in a great article in Fortune Magazine. Along with this video …

Peripheral Neuropathy

The debut of a rational treatment for an inherited neuropathy?

Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.

L-Serine Supplementation in Hereditary Sensory Neuropathy Type 1 (clinical trial)


Note that many people with Fibromyalgia also have nerve pain and symptoms that are found in peripheral neuropathy (see above), thus:

Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia. (From Harvard University and Massachusetts General Hospital, “… Although there is no cure for the genetic forms of SFPN yet, a trial of L-serine is under way for hereditary sensory and … of a small sample of patients labeled with FMS have objective evidence of a neurological cause of their CWP and other symptoms of fibromyalgia, namely SFPN …”)

Chronic Fatigue Syndrome

Supplementation with L-serine shows potential for symptom management in Chronic Fatigue Syndrome (ME/CFS)

The use of serine in the management of Chronic Fatigue Syndrome

3-PGDH, inborn Serine Deficiency Disorder

Serine deficiency is a rare, inherited, metabolic disorder that interferes with normal growth and development, particularly in the central nervous system. Unlike similar neurodevelopmental disorders, serine deficiency can be treated. Treatment benefits all children identified with serine deficiency. Early diagnosis and treatment are the key elements for the greatest success.

Serine deficiency information and links

Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency

Charcot Marie Tooth

A serine synthesis defect presenting with a Charcot-Marie-Tooth-like polyneuropathy

L-Serine Supplementation in Hereditary Sensory Neuropathy Type 1